Abstract
AbstractThe asymmetric organocatalytic conjugate addition–cyclization reaction of malonates with o‐hydroxycinnamaldehydes, which affords 4‐substituted chroman‐2‐ols, has been established using a diphenylprolinol trimethylsilyl (TMS) ether as organocatalyst. The desired products were obtained with good to excellent yields and high enantioselectivities (up to >99% ee). Synthetically useful chroman derivatives were formed after subsequent reactions.
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