Abstract

Enantiomerically pure, diastereomeric tridentate ligands bearing hydroxyl, sulfinyl, and amino moieties as nucleophiles have proven to be highly efficient catalysts in the enantioselective asymmetric direct aldol reaction giving the desired products in very high yields (up to 98%) and with ee’s of up to 97%. The influence of the stereogenic centers located on the sulfinyl sulfur atom, and on the amino moiety, on the stereochemical course of the reaction is also discussed.

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