Abstract
A highly efficient method for the construction of a family of spiro[oxazolidine-2-thione-oxindoles] with 3-isothiocyanato oxindoles and aldehydes via a cascade aldol-cyclization process has been developed. This method provides access to spiro[oxazolidine-2-thione-oxindole] derivatives bearing two vicinal quaternary/tertiary stereocenters in up to 95% yield, 98:2 dr, and 89% ee with a chiral bifunctional thiourea–tertiary amine organocatalyst based on DPEN scaffold. Good reactivity was observed and the reaction could be completed within 1.0 min.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
