Highly Efficient Suzuki–Miyaura Coupling of Aryl Tosylates and Mesylates Catalyzed by Stable, Cost‐Effective [1,3‐Bis(diphenylphosphino)propane]nickel(II) Chloride [Ni(dppp)Cl2] with only 1 mol% Loading

Abstract

AbstractWe present a highly active, inexpensive, universally applicable, and markedly stable [1,3‐bis(diphenylphosphino)propane]nickel(II) chloride [Ni(dppp)Cl2] catalyst that is capable of effecting the Suzuki–Miyaura cross‐coupling of the inherently less reactive but readily available aryl tosylates and mesylates with only 1 mol% loading and in the absence of extra supporting ligand. Under the optimized reaction conditions, cross‐coupling of a wide range of activated, non‐activated, and deactivated, as well as sterically hindered and heteroaromatic substrates (36 examples) could proceed efficiently to afford the coupled products in 53–99% yields. Consequently, the results presented in this work provide a significant advance in Suzuki–Miyaura cross‐coupling in terms of generality, practicality, and cost which are key concerns in recent research regarding transition metal‐catalyzed cross‐couplings.