Highly efficient, solvent-free esterification of testosterone promoted by a recyclable polymer-supported tosylic acid catalyst under microwave irradiation

Paweł Borowiecki,Maciej Kraszewski

doi:10.24820/ark.5550190.p011.059

Paweł Borowiecki, Maciej Kraszewski

Open Access

https://doi.org/10.24820/ark.5550190.p011.059

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Abstract

Highly efficient, solvent-free esterification of testosterone promoted by a recyclable polymer-supported tosylic acid catalyst under microwave irradiation

Highlights

Testosterone (1, androst-4-en-17β-ol-3-one or 17β-hydroxyandrost-4-en-3-one), the major male sex hormone naturally secreted by Leydig cells in the testes, is an organic molecule important from a physiological point of view [as it is essential for male sexual differentiation, growth and function of the male genital tract, masculinized secondary sexual characteristics, sexual potency, production of spermatozoa and male fertility], and from the perspective of medicinal chemistry and drug design.[1]
While testosterone constitutes a prominent example of an anabolic-androgenic steroid (AAS) substance, it is utilized for distinct androgen-requiring therapies along with male-hormone replacement therapy (M-HRT),[9,10,11] female androgen deficiency syndrome (FAIS) therapy,[12,13,14,15] and the masculinizing hormone therapy.[16,17]
We have developed an efficient, swift, cheap and environmentally friendly method for esterification of the testosterone molecule based on polymer-supported tosylic acid heterogeneous catalyst under solvent-free MW-irradiation assisted conditions

Summary

Introduction

Testosterone (1, androst-4-en-17β-ol-3-one or 17β-hydroxyandrost-4-en-3-one), the major male sex hormone naturally secreted by Leydig cells in the testes, is an organic molecule important from a physiological point of view [as it is essential for male sexual differentiation, growth and function of the male genital tract, masculinized secondary sexual characteristics, sexual potency, production of spermatozoa (spermatogenesis) and male fertility], and from the perspective of medicinal chemistry and drug design.[1]. The great majority of contemporary AAS users are not competitive athletes and they risk their health and life buying these drugs on the black market and using them primarily for personal appearance and rejuvenating effect.[37]

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