Highly efficient, asymmetric, and organocatalyst-based Henry reactions between α,β-unsaturated trifluoromethyl ketone and nitromethane

Abstract

An organocatalyst derived from quinine efficiently promoted an asymmetric Henry reaction between α,β -unsaturated trifluoromethyl ketones and nitromethane, resulting in corresponding and highly functionalized products with excellent yields and high enantioselectivities (up to 94% ee).