Abstract
An efficient and short approach to the total synthesis of flavoxate hydrochloride, a muscle relaxant in urinary bladder, is reported. The synthesis of flavoxate hydrochloride is accomplished from o -cresol in 5 steps with 60.3% overall yield using formylation with formaldehyde, Grignard reaction with ethylmagnesium bromide, oxidation with potassium permanganate, Kostanecki-Rabinson cyclization and esterification with thionyl chloride and piperidinoethanol as linear steps.
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