Abstract
A novel series of aminothiazonaphthalimides, A 1–2 and B 1–2, has been regioselectively synthesized. The linear compounds B 1–2 were evaluated to be far more active than their angular isomers A 1–2 in antitumor evaluation. The linear compounds C–F, derived from compound B 1, all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A 1 or B 1, with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A 2 or B 2, with one more methylene unit.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
