Highly Efficient and Simple Catalytic System for the N-Arylation of Some Hindered Aza-Heterocycles in Water

Abstract

A highly efficient and simple protocol for the N-arylation of some hindered aza-heterocycles in water has been developed with readily available basic copper carbonate as the catalyst using bis(3,5-dimethyl-1H-pyrazol-1-yl)methane as ligand. This mild catalytic system possesses excellent tolerance for a large variety of functional groups. A total of 11 previously unknown coupling products have been synthesized by this methodology.