Abstract
Dengue virus type 2 was isolated from a tourist who returned from Borneo to Australia. Phylogenetic analysis identified this virus as highly divergent and occupying a basal phylogenetic position relative to all known human and sylvatic dengue virus type 2 strains and the most divergent lineage not assigned to a new serotype.
Highlights
Dengue virus type 2 was isolated from a tourist who returned from Borneo to Australia
Genome sequences of DENV-2 and DENV-4 isolated from sylvatic settings occupied basal positions on phylogenetic trees of those serotypes, which suggested that each DENV serotype evolved separately in sylvatic settings before later, independent, cross-species transmission to humans in urban and semiurban settings [5,6]
We describe a highly divergent strain of DENV-2 isolated from an acutephase serum specimen from a patient in whom dengue developed after the patient returned from a vacation in Borneo to Australia in early 2015
Summary
Dengue virus type 2 was isolated from a tourist who returned from Borneo to Australia. Genome sequences of DENV-2 and DENV-4 isolated from sylvatic settings (i.e., from nonhuman primates) occupied basal positions on phylogenetic trees of those serotypes, which suggested that each DENV serotype evolved separately in sylvatic settings before later, independent, cross-species transmission to humans in urban and semiurban settings [5,6]. DENV-2 and DENV-4 have been isolated from nonhuman primates and occupy divergent phylogenetic positions, which suggests that that they are truly sylvatic.
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