Abstract

Selective NaBH4 and CeCl3·7H2O/NaBH4 mediated reduction of the carbonyl group at C-12 in 22,26-oxacholestane derivatives, prepared by regioselective acid-catalyzed opening of botogenin acetate and hecogenin acetate, provided the respective 12α-hydroxycholestanes in high yield. The structures of the products were established by NMR techniques.

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