Abstract
The highly diastereoselective cobalt-mediated cross-coupling of cyclic tert-butyldimethylsilyl-protected iodohydrins or bromohydrins with (hetero)arylmagnesium reagents has been expanded further. The method can be applied to a broad range of electron-poor and electron-rich Grignard reagents, furnishing the respective functionalized trans-2-arylcycloalcohols with diastereomeric ratios up to 99:1.
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