Abstract
Highly diastereoselective aldol additions of pure (2 R,4 S)-2- tert-butyloxazolidinone-3,4-dicarboxylic acid 3- tert-butyl ester 4-methyl ester 1 are reported. While achiral carbonyl compounds lead to mixtures of diastereomers, the double stereodifferentiation of chiral aldehydes gave a single product isomer. The relative and absolute configurations of the aldol products were assigned by NOESY.
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