Abstract
Organolithium and Grignard reagents add efficiently with very high stereoselectivity (>98% de) to a trifluoroacetaldehyde hydrazone derived from ( R)- N-benzylphenylglycinol. The addition proceeds on the re face of the chelated hydroxyhydrazone providing the ( R)-α-trifluoromethylated amine after hydrogenolysis.
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