Highly branched oligosaccharides: a general strategy for the synthesis of multiantennary N-glycans with a bisected motif.

Abstract

Squeezing in a sugar: A modular building-block approach was the strategy used in a clever general synthesis of the sterically crowded triantennary N-glycans bearing an additional bisecting GlcNAc motif (see formula). Key steps include the use of the small trifluoroacetyl protective group and the late introduction of the α1,6-arm.