Highly anti–anti selective synthesis of bis-β-amino ketones via three-component direct Mannich-type reaction of terephthalaldehyde catalyzed by ZrOCl2·8H2O

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At room temperature, zirconium oxychloride (ZrOCl2·8H2O) efficiently catalyzes the direct Mannich-type reaction of a variety of in situ generated bis-imines using terephthalaldehyde and anilines with ketones in a three-component reaction at room temperature. The reaction proceeds rapidly and affords the corresponding bis-β-amino ketones in good-to-high yields with good-to-excellent anti–anti selectivity.