Abstract
Purpose of the study HIV infection itself and antiretroviral treatment, especially nucleoside analogue reverse transcriptase inhibitors (NRTIs), cause mitochondrial impairment in HIVinfected patients, due to the inhibition of a-polymerase, the only enzyme responsible for mitochondrial DNA (mtDNA) replication. We investigated whether there are changes in mtDNA content after 1 year of treatment interruption in children.
Highlights
Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
Active antiretroviral treatment (HAART) interruption leads to an increase in mitochondrial DNA content in HIV-infected children
We investigated whether there are changes in mitochondrial DNA (mtDNA) content after 1 year of treatment interruption in children
Summary
Active antiretroviral treatment (HAART) interruption leads to an increase in mitochondrial DNA content in HIV-infected children. Address: 1Mitochondrial Research Laboratory-IDIBAPS-Hospital Clínic of Barcelona and CIBERER, Barcelona, Spain and 2Hospital Sant Joan de Déu, Barcelona, Spain. Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P143 doi:10.1186/1758-2652-11-S1-P143. Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
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