Highly Active Antiretroviral Treatment and Children

Abstract

follow-up study such as this one that we can understand the impact that HIV and its treatment with HAART has had on this unique population. What do their data show? Simply put, many of the deaths occurred in the preHAART and early HAART era, with dramatic reductions in mortality in the post-HAART era. However, they were unable to prove that it was the timing of initiation of HAART that made the biggest impact on the decrease in mortality. What are some of the confounding variables that this and other studies evaluating outcomes based on age at initiation of HAART have had to work with? In the pre-HAART era and even early in the post-HAART era, few medications were available in formulations suitable for infants and children. The problem was further compounded by lack of pharmacokinetic data on these medications in these children. These 2 issues resulted in difficulties administering these potentially lifesaving therapies to those children at highest risk for death. In this study, the lack of data on CD4 and viral load in the pre- and early HAART era in this population has also