Abstract
Highly Abundant Small Interfering RNAs Derived from a Satellite RNA Contribute to Symptom Attenuation by Binding Helper Virus-Encoded RNA Silencing Suppressors.
Highlights
Satellite RNAs are always found accompanying a helper virus (HV) upon which they are functionally dependent for replication and transmission (Palukaitis, 2016)
The miRNAs and siRNAs are transferred to Argonaute (AGO) proteins that form the core of the RNA inducing silencing complex (RISC) and guide it to inactivate, by cleavage or translational arrest, their complementary RNA
There is firm evidence supporting that RNA silencing targets plant RNA viruses, prominent among which is their ability to counteract this mechanism by encoding viral suppressors of RNA silencing (VSRs) (Csorba et al, 2015)
Summary
Satellite RNAs (satRNAs) are always found accompanying a helper virus (HV) upon which they are functionally dependent for replication (catalyzed by an RNA replicase coded in part by the HV) and transmission (following encapsidation by the HV coat protein) (Palukaitis, 2016). There is firm evidence supporting that RNA silencing targets plant RNA viruses, prominent among which is their ability to counteract this mechanism by encoding viral suppressors of RNA silencing (VSRs) (Csorba et al, 2015).
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