Abstract
Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PD ![][1] This large, randomized, controlled trial compared initial treatments in Parkinson disease. Compared to initial treatment with l-dopa, initial bromocriptine led to less motor improvement during the first years of treatment without conferring long-term advantages with respect to mortality, disability, motor complications, or quality of life. See p. 474; Editorial, p. 470 Fatigue in levodopa-naive subjects with Parkinson disease Fatigue is a frequent symptom early in the course of Parkinson disease that affects more than one-third of patients, limiting their quality … [1]: /embed/graphic-1.gif
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