Abstract
The Worldwide Innovative Networking (WIN) symposium brings together representatives from academic institutions, pharmaceutical partners, technology companies and charitable organisations from across the globe for an annual summit, discussing ongoing research and the latest developments in precision medicine. Now, in its seventh year, the aims of the WIN consortium’s annual meeting, to foster communication and collaboration between members and deliver clinical trial results that improve the care and outcomes of patients are presented in open dialogue to encourage debate and discussion.This year, the meeting was held in Paris, France from 26–27 June and consisted of six plenary sessions, two debates, and poster presentations from attendees. In keeping with the consortium’s goals, presentations and posters focused on the development and integration of new therapies and updates in genome-based medicine.Among the presentations at this year’s meeting, much of the focus fell on design and implementation of new designs of clinical trials, moving away from decades-long assessments of thousands of patients towards a nimble, adaptive design fitting the edicts of personalised medicine and delving into greater depths within genomic data, ranging beyond genome analysis to chart new targets in ligandomics, proteogenomics and more.
Highlights
When Dr Patrice Denèfle (Institute Roche for Research & Translational Medicine, France) opened proceedings of the second plenary session, it is with little surprise that he highlighted immune-based combinations and new tactics in his talk on integrating data into drug and biomarker discovery
Within the context of research conducted at COVANCE as a clinical research organisation, Dr Anderson highlighted many of the biomarkers for target and response identified by Prof Ribas, above, including neo-antigen burden, genomic instability and markers down to a patient’s history of infection in their virome as means for sorting and strategising patient approaches when treating with immune therapies
With the concluding remarks of Leroy Hood (Institute for Systems Biology, USA) again exhorting P4 systems medicine and scientific wellness, a long-view attitude to health that comes somewhere between sociology and engineering in which a healthy lifestyle with regular omni-omic surveillance can reveal cancer precursors long before a patient would normally seek treatment, the symposium drew to a close
Summary
When Dr Patrice Denèfle (Institute Roche for Research & Translational Medicine, France) opened proceedings of the second plenary session, it is with little surprise that he highlighted immune-based combinations and new tactics in his talk on integrating data into drug and biomarker discovery. In his session on histology-agnostic development of immune oncology agents, Dr Baynes reported on the immunogenic potential of cancer cells with hampered DNA damage repair, as identified via microsatellite instability assays, meaning patients may be suitable for pembrolizumab monotherapy and enrolment in combination trials.
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