Highlights from Recent Cancer Literature.

Abstract

Breaking Insights| January 18 2023 Highlights from Recent Cancer Literature Author & Article Information Online Issn: 1538-7445 Print Issn: 0008-5472 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Res (2023) 83 (2): 165–166. https://doi.org/10.1158/0008-5472.CAN-83-2-BI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record January 18 2023 Citation Highlights from Recent Cancer Literature. Cancer Res 15 January 2023; 83 (2): 165–166. https://doi.org/10.1158/0008-5472.CAN-83-2-BI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Cancer vaccines promise a broad and affordable alternative to protein and cell-based cancer immunotherapies. Utilizing SNP-7/8a, a self-assembling nanoparticle vaccine that combined expression of an engineered cancer neoantigen with a Toll-like receptor 7/8 agonist, Baharom and colleagues revealed separable importance for both CD8+ T cells and innate signaling in mediating therapeutic efficacy. Subcutaneous delivery of SNP-7/8a was sufficient to elicit a CD8+ T-cell response equivalent to intravenous SNP-7/8a. However, only intravenous delivery led to accumulation of SNP in tumors, leading to a systemic increase in inflammatory cytokines, most importantly, IFNα. Antibody blockade of IFNα signaling reversed the efficacy of intravenous SNP, as IFNα was necessary for the reduction of a subset of immunosuppressive (Chil3+) monocytes within tumors. Patients with renal cell or glial tumors expressing high levels of Chil3 exhibited worse prognoses. Expert Commentary: Effective cancer vaccines require generating antitumor CD8+ T cells and... You do not currently have access to this content.