Highlights from Recent Cancer Literature

Abstract

Breaking Insights| August 03 2022 Highlights from Recent Cancer Literature Author & Article Information Online ISSN: 1538-7445 Print ISSN: 0008-5472 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Res (2022) 82 (15): 2659–2660. https://doi.org/10.1158/0008-5472.CAN-82-15-BI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record August 3 2022 Citation Highlights from Recent Cancer Literature. Cancer Res 1 August 2022; 82 (15): 2659–2660. https://doi.org/10.1158/0008-5472.CAN-82-15-BI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search As part of the Glioma Longitudinal Analysis (GLASS) Consortium aimed at understanding glioma evolution and therapeutic vulnerabilities, Varn and colleagues analyzed over 300 glioma patients wild-type or mutant for isocitrate dehydrogenase (IDH-wt and IDH-mut, respectively), with RNA and DNA sequencing data available at multiple time points. Longitudinally, the authors discovered that the IDH-wt gliomas switched from the classical subtype to the mesenchymal subtype, whereas IDH-mut gliomas remained proneural. Moreover, IDH-wt gliomas showed increases in oligodendrocytes, neural signaling pathways, and invasion. Whereas IDH-wt glioma typically present with CDKN2A deletions, IDH-mut tumors tended to acquire deletions in CDKN2A or amplifications of CCND2 at recurrence. Myeloid cells were also implicated in driving the mesenchymal subtype of glioma at recurrence, potentially through myeloid-tumor interactions such as those mediated by oncostatin M and its receptor. Expert Commentary: Diffuse gliomas undergo several changes in cell state and molecular... You do not currently have access to this content.