Abstract
This work was for "Highland (HL) Influence on Chronic-bacterial-prostatitis (CBP) and Developing-reason of Prostate-cancer (PCa), KSA"; the purpose was to determine CBP percentage at HL "Taif"; and influence of location factors on CBP percentage and indication of its developing-reason to causing PCa. It may negatively affected other body organs and may reach death of males' society, affected marital and community life. Used medical methods for cases taster (CsT) from patients were diagnosed as suffered from CBP. That were used direct and indirect identification by "CHROMagar Orientation Medium", and "VITEK 2 System (BioMerieux, France)". The pathogenic bacteria were found in more than a quarter of the CsT as (26 and 29%). That were Staphylococcous aureus (Staph. aureus), Escherichia coli (E. coli), Staphylococcous epidermidis (Staph. epidermidis) and Streptococcus species (Strept. Spp) in (36.2%, 9.5%, 5.7% and 4.3%) respectively. Pathogenic bacteria Staph. aureus represented more than third of CsT. E. coli represented tenth and it was dangerous for its transmission from UT and GT easily. Staph. epidermidis was present on the skin and represented normal flora can easily contaminated. Strept. Spp represented less than tenth, can transferred to prostate tissue and cause CBP leading to PCa. Concluded the CBP infection was present in HL and had developing-reason for PCa, the conditions must followed to reduce it to prevent condition of turning into PCa. Recommended best periodic follow-up to detect CBP infection presence to protect against infection and its PCa developing-reason. Cases CBP infection must treated and PCa cases should not neglected or tolerated.
Highlights
CBP is an important contributing factor for PCa and / or its progression [1,2], that with detected bacterial species in PCa patients [3]
PCa associated with chronic inflammatory UT conditions as CBP [7], it associated with chronic UTI, as CBP understanding bacteria was vital in connecting dots in PCa pathogenesis [8]
E. coli detected in prostatic tissue and contributed as initiator of prostate inflammation and PCa [11]
Summary
CBP is an important contributing factor for PCa and / or its progression [1,2], that with detected bacterial species in PCa patients [3]. Bacterial species had to interact, stimulate, repress immune responses, virulent or non-virulent bacteria created inflammatory microenvironment, CBP linked with carcinogenic processes in several layers [4]. CBP created microenvironment contribute to prostate pathologies formation, UT and GT related to PCa. E. coli detected in prostatic tissue and contributed as initiator of prostate inflammation and PCa [11]. Spp found in various PCa degrees [18,19], PCa tissue, invaded prostatic tissues and induced CBP [20]. PCa prostatic fluids had E. coli higher compared to urine [21]; it had virulence properties allowed colonization resulted in inflammation and tissue damaged [22]. Statistical analysis understudy: The data were amassed, was cast-off an Excel Statistics and was shaped tables and graphs were clean presentation the intensification work data [33]
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