Abstract
SUMMARY: This brief review attempts to define high‐flux dialysis and differentiate it from low‐flux and high‐efficiency dialysis. High‐flux dialysis membranes offer improved clearance of larger‐molecular‐weight solutes, particularly β‐2 microglobulin. Patients exhibit improved cardiovascular stability and long‐term use of these membranes may delay the onset of dialysis‐related amyloidosis. Although high‐flux membranes have improved biocompatibility compared with most low‐flux membranes, this has not been demonstrated to provide morbidity or mortality benefits. Backfiltration of solutes and toxins from the dialysate to the blood is a potential but probably overstated complication of high‐flux dialysis. Most high‐flux membranes are actually efficient barriers to the passage of endotoxins. Cost is the major barrier to more widespread use of high‐flux dialysis.
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