Abstract
To the Editor: In the article by Franklin et al. (March 22 issue),1 in which infants with bronchiolitis were assigned to receive low-flow oxygen (standard-therapy group) or high-flow oxygen (high-flow group) through a nasal cannula, the primary outcomes differed between groups. Treatment failure in the standard-therapy group allowed patients to be placed in the high-flow group, whereas failure in the high-flow group resulted in unknown interventions beyond transfer to an intensive care unit (ICU). In addition, other measures of failure (such as transfer or intubation) did not favor the use of high-flow therapy. Standard therapy worked well in 566 patients, .
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