Abstract
BackgroundSarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study.DesignA cross-sectional study.Methods4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied Asian Working Group for Sarcopenia (AWGS) 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected. General linear model was done to investigate the relationship between UA and HGS/GS/SMI, adjusting age, ethnic groups, sleeping quality, education level, cognitive function, smoking history, drinking history, ADL score, and chronic disease.ResultsParticipants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a negative association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as an inverted J shape. Besides, a positive association between the UA quartiles and SMI was observed, irrespective of gender.ConclusionsOur results showed that higher uric acid levels were significantly correlated with higher muscle mass and grip strength among Chinese adults aged over 50. Higher UA serum levels might slow down the progression of sarcopenia.
Highlights
Sarcopenia was an age-dependent loss of muscle mass and function which was common among older adults, leading to disability, loss of independence and death [1]
Participants were grouped according to uric acid (UA) quartiles by gender
Our results showed that higher uric acid levels were significantly correlated with higher muscle mass and grip strength among Chinese adults aged over 50
Summary
Sarcopenia was an age-dependent loss of muscle mass and function which was common among older adults, leading to disability, loss of independence and death [1]. Sarcopenia was significantly associated with ethnicity, age, gender, obesity, life styles, chronic disease and so on [3]. In addition to these risk factors, age-related decreases in hormone concentrations could cause loss of muscle mass and strength, such as growth hormone, testosterone, thyroid hormone, vitamin D, albumin and insulin-like growth factor [4]. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study
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