Abstract
Background: Changes in thyroid stimulating hormone (TSH) and thyroid hormone levels, mostly in the form of non-thyroidal illness syndrome (NTIS), have been described in many disease entities including myocardial infarction and sepsis. However, the relationship of acute liver failure (ALF) and thyroid hormone levels has not yet been clarified. The purpose of our present study was to evaluate potential correlations of select thyroid functional parameters with ALF. Methods: 84 consecutively recruited ALF patients were divided in groups according to the outcome of ALF (spontaneous recovery: SR; transplantation or death: NSR). TSH, free thyroxine (fT4), free triiodothyronine (fT3), total thyroxine (TT4), and total triiodothyronine (TT3). NTIS was defined as low or normal TSH, low fT3 or low fT4 without known pre-existing thyroid illness. Results: More than 50% of patients with ALF presented with abnormal thyroid parameters. These patients had a greater risk for an adverse outcome than euthyroid patients. Patients in the SR group had significantly higher TSH, TT4, and TT3 (but not fT4) concentrations than NSR patients. Albumin concentrations were significantly higher in SR than in NSR.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
