Abstract
BackgroundIt is well known that a low skeletal muscle mass (SMM) is associated with stroke. However, it is unknown whether increasing muscle mass can prevent stroke.MethodsThis community-based cross-sectional study was supported by the regional government. SMM measurements and brain computed tomography was performed in 722 stroke-free and dementia-free subjects (aged 50–75 years). Subjects were divided into quartiles (Q) by SMM, checked using the bioelectrical impedance analysis method (InBody 770, InBody, Seoul, Korea). Odds ratios (ORs) of brain white matter changes/silent infarction (WMC/SI) were calculated. The subjects were then divided into two groups by sex and evaluated.ResultsIn the analysis of the four groups, the unadjusted ORs of Q2–Q4 were 0.616 (95% confidence interval [CI], 0.372–1.022; P = 0.061), 0.290 (CI, 0.159–0.530; P < 0.001), and 0.209 (CI, 0.108–0.403; P < 0.001) for the risk of WMC/SI. Adjusted ORs for age, hypertension, diabetes mellitus, education, hypercholesterolemia, and smoking were 0.994 (CI, 0.513–1.740; P = 0.085), 0.669 (CI, 0.329–1.362; P = 0.268), and 0.464 (CI, 0.219–0.984; P = 0.045). In the two–group (dichotomized) analysis, the unadjusted OR for the higher muscle mass groups (Q3 + Q4) was 0.313 (CI, 0.200–0.491; P < 0.001). The adjusted OR was 0.577 (CI, 0.340–0.979; P = 0.042). Considering sex, the adjusted OR were 0.351 (CI, 0.141–0.869; P = 0.024) in men and 0.771 (CI, 0.391–1.519; P = 0.452) in women.ConclusionsOur findings suggest that increased SMM may protect against WMC/SI, especially in men.
Highlights
It is well known that a low skeletal muscle mass (SMM) is associated with stroke
Our study investigated the correlation between SMM and White matter changes (WMC)/Silent infarction (SI) in a community-based setting
The subjects in the white matter changes/silent infarction (WMC/SI) group were older, had a higher incidence of hypertension and diabetes mellitus (DM), and had lower education levels compared to the normal brain Computed tomography (CT) group (Table 1)
Summary
It is well known that a low skeletal muscle mass (SMM) is associated with stroke. It is unknown whether increasing muscle mass can prevent stroke. Contraction of skeletal muscle secret myokines and block the inflammatory signaling pathways generated by chronically elevated levels of pro-inflammatory adipokines [6] Muscle mass can be increased by weight training exercise. It is unknown whether increased muscle mass can prevent stroke. We hypothesized that increased SMM can prevent stroke after middle age
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