Abstract
Interleukin (IL) receptor expression has been shown to increase significantly during maternal immune activation. It has been suggested that dysfunctional Interleukin activity is associated with cortical dysplasia and ASD-like behaviors. We measured the concentration of 30 cell receptors, including 5 Interleukin receptors (IL-1R, IL-2R, IL-10R, IL-17R and IL-21R) from mothers with at least one autistic child and neurotypical, gender and age similar controls, using immune-arrays. Of the 5 Interleukin receptors, 4 (IL-1R, IL-10R, IL-17R and IL-21R) had concentrations significantly higher in mothers of autistic children, when compared to neurotypical controls.
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