Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study

Yue Chen,Xu Han,Binhao Wang,Yunlong Xia,Bin Waleed Khalid,Haixu Yu,Huihua Li,Xumin Guan,Wenyu Li,Shouling Wu,Yiheng Yang

doi:10.1038/s41598-018-22868-8

Abstract

We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in a community based population. A total of 101,510 participants were recruited at baseline (2006–2007). The follow-up visits were conducted every two years. Participants who were free from PVC at baseline and achieved the fourth visit, or diagnosed of PVC during the subsequent visits were included for analyses. Diagnosis of PVC was based on standard supine resting, 10-s 12-lead ECG. Cox regression was applied to evaluate the association between quartiles of hs-CRP and the incidence of PVCs. 60710 participants (male: 79.9%, mean age 49.4 years) were included for analyses. During a mean follow-up of 74.9 ± 7.4 months, 908 (1.5%) participants were diagnosed with PVC. Participants of the highest quartile of hs-CRP had significantly increased risk of PVC events as compared with the lowest quartile (HR 1.36; 95% CI 1.12–1.66); and stratified analyses showed similar result in males (HR 1.45; 95% CI 1.16–1.80), but not in females (HR 1.12; 95% CI 0.71–1.79). Moreover, elevated serum hs-CRP was associated with future PVC in participants without history of myocardial infarction or stroke (HR 1.34; 95% CI 1.09–1.65). Elevated hs-CRP was an independent predictor of PVC in Chinese population, especially in men.

Highlights

We aimed to determine whether high-sensitive c reactive protein (hs-CRP) is a predictor of future premature ventricular contraction (PVC) events in a community based population
Exclusion criteria included: (1) missing data of ECG or hs-CRP, (2) history with atrial fibrillation/flutter or Wolff Parkinson White (WPW) syndrome at baseline, (3) PVC was diagnosed in the first health examination, (4) participants with hs-CRP concentration >10 mg/l, which may be reflective of an acute inflammation[16] (Fig. 1)
Compared with the first hs-CRP quartile, Participants of the higher quartile of hs-CRP were associated with higher prevalence of cardiovascular risk factors, including hypertension, Diabetes mellitus (DM), MI, stroke, high body mass indexes (BMI), advanced age, and elevated concentrations of systolic Blood pressure (BP), diastolic BP, fasting blood glucose (FBG)

Summary

Introduction

We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in a community based population. Cox regression was applied to evaluate the association between quartiles of hs-CRP and the incidence of PVCs. 60710 participants (male: 79.9%, mean age 49.4 years) were included for analyses. Elevated serum hs-CRP was associated with future PVC in participants without history of myocardial infarction or stroke (HR 1.34; 95% CI 1.09–1.65). In view of the fact that hs-CRP has been involved in the pathogenesis of many cardiovascular events, we hypothesized that elevated hs-CRP may predict PVC events In this community based prospective cohort study, we evaluated the effects of baseline hs-CRP level on the incidence of future PVC www.nature.com/scientificreports/. Stratified analyses were performed to evaluate the potential influence of gender and other clinical characteristics on the association between hs-CRP and PVC risk

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