Abstract
BackgroundThe aim of this study was to evaluate the differences in upper gastrointestinal symptoms between generations and genders in relatively healthy Japanese subjects.MethodsAltogether, 4086 healthy Japanese male and female (M/F) adults (M/F: 2244/1842) were analyzed. Among them, 3505 subjects (M/F: 1922/1583) were underwent a routine medical checkup at one of five hospitals in Saga, Japan from January 2013 to December 2013. The others were 581 (M/F: 322/259) healthy young volunteers at the Saga Medical School from April 2007 to March 2013. The participants were asked to complete the frequency scale for the symptoms of gastroesophageal reflex disease (FSSG) questionnaire, undergo upper gastrointestinal endoscopy, and submit to a rapid urease test to diagnose Helicobacter pylori infection. Among the 4086 subjects, the 2414 who had no H. pylori infection and no positive endoscopic findings were enrolled in the study.ResultsSubjects’ average age was 46.9 ± 12.2 years, with males’ and females’ ages being almost equivalent. The total FSSG score were high in females compared to males (P < 0.01) and decreased significantly with aging (P < 0.05). Among the generations, FSSG scores were the highest for those 20–29 years old, and they were significantly decreased with ageing in both males and females (P < 0.05).ConclusionThe FSSG score was significantly higher in healthy Japanese females than in males, and the scores decreased with aging.
Highlights
Annual public health surveys conducted by the Ministry of Health, Labor, and Welfare of Japan in 2013 indicated that 27.7% of men and 31.2% of females had some type of clinical symptoms [1]
The present study aimed to examine; (1) whether the upper gastrointestinal symptoms evaluated by FSSG were different between relatively healthy male and female Japanese subjects, and (2) whether the tendency evaluated in these two groups was affected by aging
Our previous studies indicated that, among relatively healthy subjects, females complained of upper gastrointestinal symptoms more commonly than males in the younger generations [6, 16] and middle-aged to older generations [7, 17]
Summary
Annual public health surveys conducted by the Ministry of Health, Labor, and Welfare of Japan in 2013 indicated that 27.7% of men and 31.2% of females had some type of clinical symptoms [1]. A Japanese study of the clinical signs and symptoms of gastroesophageal reflux disease (GERD) developed a frequency scale for the symptoms of GERD (FSSG). It is a questionnaire for use with Japanese subjects and covers most upper gastrointestinal symptoms [8]. The present study aimed to examine; (1) whether the upper gastrointestinal symptoms evaluated by FSSG were different between relatively healthy male and female Japanese subjects, and (2) whether the tendency evaluated in these two groups was affected by aging. The aim of this study was to evaluate the differences in upper gastrointestinal symptoms between generations and genders in relatively healthy Japanese subjects. Conclusion The FSSG score was significantly higher in healthy Japanese females than in males, and the scores decreased with aging
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