Abstract
PurposeType 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications.MethodsA total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25–39) years and disease duration 13 (IQR: 8–19) years] in euthyroid state with negative history for hypothyroidism were included to the study. Participants were screened for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and FT3. Moreover, microangiopathic complications (retinopathy, diabetic kidney disease, peripheral and autonomic neuropathy), markers of metabolic control such as glycated hemoglobin (HbA1c) were evaluated.ResultsA total of 114 (42.9%) people had diagnosed at least one microangiopathic complication. In multivariable linear regression higher HbA1c was statistically significant independent predictor of lower FT3 (β = −0.25; p < 0.0001) after adjustment for sex, T1DM duration, HbA1c, waist-to-hip ratio (WHR) (R2 = 0.15, p < 0.0001). Higher FT3 was simultaneously a predictor of lower prevalence of microangiopathy in multivariate logistic regression analysis (odds ratio, 0.51; 95% confidence interval, 0.27–0.98; p = 0.04) after an adjustment for: age, hypertension, HbA1c, WHR and total cholesterol (TC).ConclusionsFT3 as tissue active hormone plays a clinically important role in T1DM people. The higher FT3 concentration is related to the lower prevalence of microangiopathy and better metabolic control of the disease in adult euthyroid people with T1DM.
Highlights
Thyroid hormones are crucial for energy homeostasis and regulation of metabolism pace
**125 participants had FT4 assessed (34 with microangiopathy, 91 without microangiopathy) aχ2 test; Mann–Whitney U test in every other case, where it is not marked with the letter
The most important result obtained in this study was a higher concentration of FT3 in euthyroid type 1 diabetes mellitus (T1DM) participants without presence of microvascular complications in comparison to the participants with microangiopathy
Summary
Thyroid hormones are crucial for energy homeostasis and regulation of metabolism pace They affect metabolism both centrally in connection with the hypothalamus and peripherally through key targets, such as the brown and white. There are not a lot of studies assessing thyroid impact on clinical features in the course of type 1 diabetes mellitus (T1DM). The phenomenon of transient disorder of thyroid function is generally described as an euthyroid sick syndrome or nonthyroidal illness syndrome or low T3 syndrome [3]. This state is connected with acute or chronic disorders of various. Examined populations contained both euthyroid and hypothyroid participants [5,6,7,8]
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