Abstract
Objective:To investigate the possible effect of follicular fluid glycodelin levels on the quality of developing oocytes and subsequent in vitro embryo development.Methods:Follicular fluid glycodelin levels of 145 patients undergoing assisted reproductive treatment were analyzed and the correlation between glycodelin levels and ART outcomes were evaluated.Results:We found that glycodelin levels were negatively correlated with the number of high quality embryos on day 3 (r=-0.20, p=0.05). Additionally, higher glycodelin levels were correlated with higher FSH levels (r=0.18, p=0.04). However, glycodelin levels were not predictive for implantation (p=0.67) or ongoing pregnancy rates (p=0.99).Conclusion:Glycodelin in the follicular environment might be one of the factors that influence the competence of growing oocytes and affect the quality of subsequent in vitro embryo development.
Highlights
The follicular microenvironment of the oocyte is composed of theca and granulosa cells and follicular fluid
In order to investigate the possible association of Gd among different female infertility groups, we compared the follicular fluid Gd levels of groups diagnosed with ovulatory factor, tubal factor, and unexplained infertility
Gd secretion is induced by progesterone in the endometrium, no correlation was observed between these molecules in our data (p=0.14)
Summary
The follicular microenvironment of the oocyte is composed of theca and granulosa cells and follicular fluid All such components play critical roles in the development of competent oocytes and in the formation of high quality embryos (Dumesic et al, 2015; Sirard et al, 2006). The dynamics in this environment is highly orchestrated through the messengers in the follicular fluid such as miRNAs, cytokines, hormones, peptides and other molecules (Revelli et al, 2009). Gd is primarily synthesized in the reproductive tract, its expression was detected in other tissues such as the bone marrow (Kämäräinen et al, 1994) and gynecological tumors (Horowitz et al, 2001; Kämäräinen et al, 1996)
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