Abstract
Elevated recipient circulating cell-free hemoglobin (CFH) prior to lung transplant is an independent risk factor for primary graft dysfunction (PGD) (JHLT 2013;32:S42-3). This association is augmented by higher reperfusion FiO2, but the mechanisms of this are unknown. We hypothesized that hyperoxia increases PGD risk through oxidation of CFH, resulting in lung endothelial injury and vascular permeability.
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