Abstract
BackgroundFibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. However, no data is currently available regarding the association of fibrinogen level with the presence and severity of new-onset coronary atherosclerosis assessed by Gensini score (GS), particularly in Han Chinese with a large sample size.Methods and ResultsWe studied 2288 consecutive, new-onset subjects undergoing coronary angiography with angina-like chest pain. Clinical and laboratory data were collected. Coronary stenotic lesions were considered to be the incidence of coronary atherosclerosis. The severity of coronary stenosis was determined by the GS system. Data indicated that patients with high GS had significantly elevated fibrinogen level (p<0.001). The prevalence and severity of coronary atherosclerosis were dramatically increased according to fibrinogen tertiles. Spearman correlation analysis revealed a positive association between fibrinogen level and GS (r = 0.138, p<0.001). Multivariate logistic regression analysis demonstrated that plasma fibrinogen level was independently associated with high GS (OR = 1.275, 95% CI 1.082–1.502, p = 0.004) after adjusting for potential confounders. Moreover, fibrinogen level was also independently related to the presence of coronary atherosclerosis (fibrinogen tertile 2: OR = 1.192, 95% CI 0.889–1.598, p = 0.241; tertile 3: OR = 2.003, 95% CI 1.383–2.903, p <0.001) and high GS (fibrinogen tertile 2: OR = 1.079, 95% CI 0.833–1.397, p = 0.565; tertile 3: OR = 1.524, 95% CI 1.155–2.011, p = 0.003) in a dose-dependent manner. Receiver-operating characteristic curve analysis showed that the best fibrinogen cut-off value for predicting the severity of coronary stenosis was 3.21 g/L.ConclusionsHigher fibrinogen level is independently linked with the presence and severity of new-onset coronary atherosclerosis in Han Chinese population.
Highlights
Coronary atherosclerosis is the major cause of associated morbidity and mortality in the world
No data is currently available regarding the association of fibrinogen level with the presence and severity of new-onset coronary atherosclerosis assessed by Gensini score (GS), in Han Chinese with a large sample size
Multivariate logistic regression analysis demonstrated that plasma fibrinogen level was independently associated with high GS (OR51.275, 95% CI 1.082–1.502, p50.004) after adjusting for potential confounders
Summary
Coronary atherosclerosis is the major cause of associated morbidity and mortality in the world. Multiple epidemiologic along with case-control studies revealed an association between the increased fibrinogen level and the early signs of atherosclerosis in asymptomatic individuals [7, 8]. The increased fibrinogen level has been identified as an important risk factor for the future cardiovascular events in apparently healthy individuals [9, 10] and in patients with established coronary artery disease (CAD) [11,12,13]. No data is currently available regarding the association of fibrinogen level with the presence and severity of new-onset coronary atherosclerosis assessed by Gensini score (GS), in Han Chinese with a large sample size. Multivariate logistic regression analysis demonstrated that plasma fibrinogen level was independently associated with high GS (OR51.275, 95% CI 1.082–1.502, p50.004) after adjusting for potential confounders. Receiver-operating characteristic curve analysis showed that the best fibrinogen cut-off value for predicting the severity of coronary stenosis was 3.21 g/L
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