Higher dimensional analysis shows reduced dynamism of time-varying network connectivity in schizophrenia patients.

Abstract

Assessments of functional connectivity between brain networks is a fixture of resting state fMRI research. Until very recently most of this work proceeded from an assumption of stationarity in resting state network connectivity. In the last few years however, interest in moving beyond this simplifying assumption has grown considerably. Applying group temporal independent component analysis (tICA) to a set of time-varying functional network connectivity (FNC) matrices derived from a large multi-site fMRI dataset (N=314; 163 healthy, 151 schizophrenia patients), we obtain a set of five basic correlation patterns (component spatial maps (SMs)) from which observed FNCs can be expressed as mutually independent linear combinations, i.e., the coefficient on each SM in the linear combination is maximally independent of the others. We study dynamic properties of network connectivity as they are reflected in this five-dimensional space, and report stark differences in connectivity dynamics between schizophrenia patients and healthy controls. We also find that the most important global differences in FNC dynamism between patient and control groups are replicated when the same dynamical analysis is performed on sets of correlation patterns obtained from either PCA or spatial ICA, giving us additional confidence in the results.