Abstract
BackgroundHigh carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease (CHD) risk remains unclear. The aim of this study was to explore the potential association in a Chinese older population.MethodsIn a population-based case-control study conducted in a Chinese older population, serum CA-125 levels were measured in 1177 diagnosed CHD patients and 3531 age and sex matched control subjects without CHD.ResultsSerum CA-125 level was significantly higher in CHD patients than controls (P < 0.001) with adjustment for age, gender, smoking, drinking, BMI, physical activity, hypertension, dyslipidemia, diabetes mellitus, medication history and family history of CHD and myocardial infarction. CHD risk was doubled (OR: 2.10, 95%CI: 1.69-2.60) among subjects in the highest quartile compared to those in the lowest quartile of CA-125 level (P trend < 0.001). Furthermore, CA-125 levels were associated with CHD risks in subjects with age over 60 years (OR: 2.19, 95%CI: 1.75-2.73), current smokers (OR: 2.29, 95%CI: 1.50-3.49), current drinkers (OR: 2.35, 95%CI: 1.57-3.53) and subjects with hypertension (OR: 2.04, 95%CI: 1.71-2.43).ConclusionsElevated serum CA-125 level might be associated with increased risk of coronary heart disease in the Chinese older population. Further investigations are needed to identify the possible biological role of CA-125 in CHD development in the future.
Highlights
carbohydrate antigen 125 (CA-125) (Carbohydrate antigen 125) is a well-established tumor marker to monitor the efficacy of ovarian cancer therapy and early detect its recurrence [1]
We divided the 1177 coronary heart disease (CHD) cases into two groups: CHD accompanying with MI (210, Table S1) and CHD without MI (967, Table S2), and compared the two groups with controls (3531) respectively, the adjusted over years (OR) of CHD patients accompanying with MI in highest quartile of CA-125 level was 2.76 (95%CI: 1.73-4.41, P < 0.001), and that of CHD patients without MI was 2.02 (95%CI: 1.61-2.54, P < 0.001) after adjustment for age, gender, smoking, drinking, Body mass index (BMI), physical activity, hypertension, dyslipidemia, diabetes mellitus, medication history and family history of CHD and myocardial infarction
In this population-based case-control study, we investigated the association between serum CA-125 level and the risk of CHD in a large Chinese older population for the first time
Summary
CA-125 (Carbohydrate antigen 125) is a well-established tumor marker to monitor the efficacy of ovarian cancer therapy and early detect its recurrence [1] It is elevated in both ovarian and non-ovarian diseases, malignant and nonmalignant conditions [2]. Few studies have investigated whether the higher concentration of serum CA-125 is associated with the increased risk of coronary heart disease (CHD) or not until now. High carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease (CHD) risk remains unclear. Conclusions: Elevated serum CA-125 level might be associated with increased risk of coronary heart disease in the Chinese older population. Further investigations are needed to identify the possible biological role of CA-125 in CHD development in the future
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
