Abstract
BackgroundThe association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear,MethodA total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses.ResultBMI was linearly related to the OS (total P = 0.004, nonlinear P = 0.124). BMI was analyzed as categorical data based on X-tile software-defined cutoffs and World Health Organization (WHO)-recommended cutoffs. Adjusted with confounding covariates, higher BMI manifested as a positive prognostic predictor. Furthermore, BMI was proven to be associated with the OS in the PS analysis. (UnderweightXtile vs. NormalXtileP = 0.003, OverweightXtile vs. NormalXtileP = 0.019; UnderweightWHO vs. NormalWHOP < 0.001, OverweightWHO vs. NormalWHOP = 0.024). It was also revealed that patients with higher BMI benefitted more from chemotherapy. (Adjusted hazard ratio (aHR): UnderweightXtile vs. NormalXtile vs. OverweightXtile: 0.565 vs. 0.474 vs. 0.409; UnderweightWHO vs. NormalWHO vs. OverweightWHO: 0.613 vs. 0.464 vs. 0.425).ConclusionAmong PDAC patients, there was a positive association between BMI and the OS, especially in patients treated with chemotherapy.
Highlights
The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, Method: A total of 2010 patients from a high-volume center were enrolled in the study
Patients and characteristics 2010 patients were enrolled in this study, and the baseline data were displayed in Table 1 and Supp
The whole cohort consisted of 192 Ia (9.6%), 478 Ib (23.8%), 155 IIa (7.7%), 532 IIb (26.5%), 432 III (21.5%) and 221 IV (11%) stage patients
Summary
The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, Method: A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses. Body mass index (BMI), an accessible and inexpensive parameter, has been reported to be associated with the incidence of pancreatic cancer [3, 4]. It was discovered that there was an association between higher BMI and better OS among PDAC patients [5]. In this study, relying on propensity score (PS) analysis and multivariable risk adjustment analysis, we sought for the association between BMI and the OS.
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