Abstract
BackgroundEmerging studies indicate that B-type natriuretic peptide (BNP), a well-known biomarker for heart failure, also plays pivotal roles in metabolic control. Circulating BNP levels progressively increase as ages grow older. However, the association between BNP levels and lipid metabolism in the elderly remains unknown.MethodsA total of 680 eligible volunteers (male/female: 334/346) aged between 60 and 80 years old without overt heart failure (BNP <100 pg/ml) were enrolled. Random nonfasting venous samples were obtained for biochemical analysis. The subjects were stratified based on BNP quartiles: BNP Q1 (range: 2.2–9.0 pg/ml), Q2 (9.1–20.4 pg/ml), Q3 (20.5–44.4 pg/ml) and Q4 (44.6–99.7 pg/ml). Difference of metabolic parameters was compared among the subjects grouped by BNP quartiles. Univariate correlation and multiple linear regression were performed to analyze the association between BNP levels and metabolic parameters. The odds ratios (OR) and 95 % confidence intervals (CI) for dyslipidemia in subjects within BNP Q1-3 relative to subjects within BNP Q4 were calculated.ResultsCirculating BNP levels positively correlated with age, while negatively correlated with body mass index (BMI), eGFR and non-HDL. Subjects with lower BNP quartiles had significantly elevated prevalence of dyslipidemia, including hypertriglyceridemia, hyper-LDL-emia and hypercholesterolemia. The OR of hypertriglyceridemia and hypercholesterolemia for subjects within BNP Q1-2 significantly increased relative to BNP Q4.ConclusionsThe elderly people with higher BNP levels have significantly reduced risks for nonfasting dyslipidemia. Verification of the cause-effect relationship between BNP and dyslipidemia may bring therapeutic implications.
Highlights
Emerging studies indicate that B-type natriuretic peptide (BNP), a well-known biomarker for heart failure, plays pivotal roles in metabolic control
We found that the elderly people with higher BNP levels tended to have reduced prevalence of hypertriglyceridemia, hypercholesterolemia and hyper-LDL-emia, which supports the beneficial roles of BNP in lipid metabolism
The subjects were divided into four quartiles according to BNP levels
Summary
Emerging studies indicate that B-type natriuretic peptide (BNP), a well-known biomarker for heart failure, plays pivotal roles in metabolic control. BNP is predominantly expressed by ventricular cells and correlates better with the severity of heart failure than ANP, so BNP has gained more intense researches as a clinically useful biomarker [1, 2]. Higher BNP levels are often associated with adverse cardiovascular outcomes [3, 4], growing evidence has demonstrated that elevated BNP plays beneficial roles in metabolic regulation under non-heart failure settings. BNP directly promotes mitochondrial biogenesis in skeletal muscles and white adipocytes to enhance energy expenditure [10, 11].
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