Abstract
Obesity triggers alterations in hemodynamic and autonomic control. There are few studies that investigate the effects of overweight and obesity in early adulthood on hemodynamic and autonomic variables. The aim of this study was to determine whether overweight and obesity in young individuals cause alterations in hemodynamic parameters and heart rate variability (HRV) in supine and seated position, and to correlate these variables with anthropometric features. Measurements were performed in 40 young untrained male study participants. The subjects were eutrophic (22.8 ± 0.3 kg/m2, N = 19), overweight (27.0 ± 0.5 kg/m2, N = 10), and obese (33.5 ± 0.8 kg/m2, N = 11). After 5 min in supine and seated position, the R-R intervals and blood pressure (BP) were recorded. The systolic blood pressure were higher in overweight (supine, 122.9 ± 2.3 mmHg) and obese (supine, 123.9 ± 2.2; seated, 121.7 ± 2.3 mmHg) individuals compared to eutrophic individuals (supine, 111.8 ± 1.64; seated, 111.3 ± 1.8 mmHg) (p ⩽ 0.05). Obese subjects exhibited lower HRV (SD1, RMSSD, pNN50) compared to eutrophic individuals when seated. In obese subjects, the heart rate (HR) increased and HRV decreased (p ≤ 0.05) when seated versus supine position. The body mass, body mass index (BMI), and waist and abdominal circumferences correlated positively with BP (r = 0.40-0.64, p ≤ 0.05), while the BMI, waist circumference, BP, and HR were negatively correlated (r = -0.32 -0.62, p ≤ 0.05) with HRV (pNN50 and HF) in both body positions. BMI, waist circumference, BP and HR correlated negat- ively with additional HRV indices (SD1, SD2, RMSSD, TP, and LF) when seated. Obese and overweight individuals presented higher SBP, and obese individuals had lower HRV and cardiac vagal activity, associated with anthropometric variables. The monitoring of HRV in obese subjects in seated position allows improved prognosis of metabolic consequences to cardiac autonomic control.
Highlights
Introduction problems around the worldGlobal epidemiological statistics revealed that the prevalence of overweight and obesity in menEach year, about 2.6 million people die from obesity-related was 36.9% in 2013 [1]
The systolic blood pressure were higher in overweight and obese individuals compared to eutrophic individuals (p ≤ 0.05)
In line with the body mass and body mass index (BMI), the waist (WC) and abdominal (AC) circumferences were in the order of obese individuals > overweight individuals > eutrophic individuals
Summary
Introduction problems around the worldGlobal epidemiological statistics revealed that the prevalence of overweight and obesity in menEach year, about 2.6 million people die from obesity-related was 36.9% in 2013 [1]. Obesity leads to reduced vagal nervous activity and maintenance or an increase in sympathetic nervous activity Both affect heart rate (HR) and the baroreflex system, which detects and responds to changes in BP and corollary arterial dispensability and regulates HR [4]. Aim: The aim of this study was to determine whether overweight and obesity in young individuals cause alterations in hemodynamic parameters and heart rate variability (HRV) in supine and seated position, and to correlate these variables with anthropometric features. Obese subjects exhibited lower HRV (SD1, RMSSD, pNN50) compared to eutrophic individuals when seated. The heart rate (HR) increased and HRV decreased (p ≤ 0.05) when seated versus supine position. Relevance for patients: The monitoring of HRV in obese subjects in seated position allows improved prognosis of metabolic consequences to cardiac autonomic control
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