Abstract
The profile of metabolic changes in the ischemic heart following repeated infusions of cardioplegic solution has not been well characterized in cardiac hypertrophy. In this study we evaluated the effect of mild cardiac hypertrophy on the changes in phosphocreatine (PCr) and ATP throughout a cardioplegic arrest/ischemia/reperfusion experimental protocol (see Fig. 1). In addition to metabolic status, mechanical recovery of systolic and diastolic function was evaluated in the same hearts.
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