Abstract
Kawasaki Disease (KD) is an acute systemic vasculitis of unknown etiology in infants and young children, and it is frequently associated with coronary artery aneurysms. High-dose infusion of IgG (IVIG) effectively reduces systemic inflammation and the incidence of coronary artery lesions in 80-90% of KD. However, for reasons that remain unclear, some patients do not respond to IVIG. In order to obtain clues to the cause of IVIG resistance, we compared the in vitro effects of high-dose IgG on cultured human coronary artery endothelial cells (HCAECs) exposed to various inflammatory stimuli.
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