Abstract
R-(−)-[ 11C]Epinephrine ([ 11C]EPI) has been synthesized from R-(−)-norepinephrine by direct methylation with [ 11C]methyl iodide or [ 11C]methyl triflate. The total synthesis time including HPLC purification was 35–40 min. The radiochemical yields (EOB) were 5–10% for [ 11C]methyl iodide and 15–25% for [ 11C]methyl triflate. Radiochemical purity was >98%; optical purity determined by radio-chiral HPLC was >97%. The [ 11C]methyl triflate technique produces R-(−)-[ 11C]epinephrine in quantities (80–170 mCi) sufficient for multiple positron emission tomography studies in humans. The two synthetic methods are generally applicable to the production of other N-[ 11C]methyl phenolamines and N-[ 11C]methyl catecholamines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
