Abstract
We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 ug/mL) was the only independent risk factor for development of complicated bacteremia caused by methicillin-susceptible S. aureus (odds ratio 22.9, 95% confidence interval 6.7-78.1).
Highlights
We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest
The aim of our study was to evaluate whether vancomycin MIC has any influence on the death rates and outcomes of patients with catheter-related methicillinsusceptible S. aureus (MSSA) bacteremia
A first relevant finding of our study was the relatively high incidence of high vancomycin MIC among MSSA strains producing bacteremia (23.2%), a result similar to the percentage found for methicillin-resistant Staphylococcus aureus (MRSA) strains in our hospital [9,10]
Summary
Jose Maria Aguado, Rafael San-Juan, Antonio Lalueza, Francisca Sanz, Joaquin Rodríguez-Otero, Carmen Gómez-Gonzalez, and Fernando Chaves. We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 μg/mL) was the only independent risk factor for development of complicated bacteremia caused by methicillin-susceptible S. aureus (odds ratio 22.9, 95% confidence interval 6.7– 78.1). The Study We retrospectively determined the MIC of vancomycin for the first MSSA blood culture isolate from a cohort of 99 adult patients with catheter-related bacteremia. These patients were consecutively evaluated from January 2002 through December 2004 (mean follow-up 3 years) in University Hospital 12 de Octubre in Madrid, Spain, a 1,000-bed university medical center. Among the 64 patients treated initially with glycopeptides, the rate of complicated bacteremia was significantly higher in patients with high vancomycin MIC isolates (15/18 [83.3%] vs. 8/46 [17.4%]; p
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
