Abstract
TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarcinoma (PAAD) is still unclear. The present study was designed to examine the expression profile of TXLNA and explore its prognostic significance in PAAD patients and the possible molecular regulatory mechanism by analyzing a series of data from databases, including GEPIA, LOGpc, STRING, and GeneMANIA. The results indicate that TXLNA mRNA and protein were remarkably increased in PAAD tissues compared with normal pancreatic tissues. The high TXLNA expression was significantly correlated with superior overall survival (OS), disease-free interval (DFI), disease specific survival (DSS), and progression-free interval (PFI) for PAAD patients. In summary, high TXLNA expression could predict favourable OS, DFI, DSS, and PFI for PAAD patients, and it might be as potential prognostic biomarkers and targets for PAAD.
Highlights
Pancreatic cancer (PC) is one of the leading causes of cancer mortality, resulting in a substantial global burden [1]
Taxilin alpha (TXLNA) was identified as a binding partner of the syntaxin family [6]. e TXLNA was named interleukin 14 (IL-14), and its alternative gene name was designated as TXLNA or IL14 in the NCBI. e function of TXLNA was identified as a key factor in the coordination of intracellular vesicle trafficking [6]. e syntaxin family was composed of three members, including alpha (α), beta (β), and gamma (c)-taxilin
Li et al had found that the combination of SRPX2 and RAB31 were independent prognostic factors that associated with overall survival (OS) and DFS of pancreatic cancer [20]
Summary
Pancreatic cancer (PC) is one of the leading causes of cancer mortality, resulting in a substantial global burden [1]. E syntaxin family was composed of three members, including alpha (α)-, beta (β)-, and gamma (c)-taxilin. Taxilin alpha (TXLNA) was identified as a binding partner of the syntaxin family [6]. They share an extraordinarily long coiled-coil region homologous to that of Uso, a yeast tethering factor homolog of p115 [7]. E relationship between TXLNA and pancreatic cancer prognosis remains to be determined. e present study was designed to evaluate the expression profile of TXLNA and to investigate its prognostic significance for PAAD patients
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