Abstract
Aim: To define high tumor burden (HTB) in non-small-cell lung cancer. Methods: A total of fiveoncologists initiated the project, selecting 66 participants, and elaborated a questionnaire with 26 statements using the Delphi method with a 9-point Likert scale of agreement. Results: Factors with moderate strength of consensus wereidentified, including a sum of the longest diameter of lesions ≥10cm, elevatedLDH, hepatic involvement, lymphangitis carcinomatosis, brain involvement unapproachable with local techniques and pericardial effusion. There was a consensus against increases intumor markers and asymptomatic brain involvement being related to HTB. HTB was considered a relevant factor for treatment selection supporting thechoice of combination regimens versus immunotherapy only. Conclusion: In this Delphi study, experts defined several factors associated with HTB in non-small cell lung cancer.
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