Abstract
Tripartite motif containing 44 (TRIM44) has been reported to be up-regulated in multiple aggressive malignant tumors. However, its expression status and clinical significance in cervical cancer remain unknown. The purpose of this study was to investigate the clinical significance of TRIM44 expression and the prognosis in patients with cervical cancer (CC). Fresh frozen tissues from 5 samples of CC and 4 normal cervical tissues were analyzed for TRIM44 expression using RT- PCR and Western blot analysis. 122 paraffin-embedded surgical specimens from patients with CC were collected for an immunohistochemistry. TRIM44 expression was found to be significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues (P<0.001). Statistical analysis showed that TRIM44 expression was significantly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade and lymph node metastasis, but not with age, histological type, and tumor size. Kaplan–Meier survival analysis suggested that high TRIM44 expression was associated with poor prognosis. Patients highly expressing TRIM44 have significantly shorter overall survival (OS) (P=0.006) and disease-free survival (DFS) (P=0.002). Furthermore, multivariate Cox analysis showed TRIM44 was an independent risk factor for poor prognosis. Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer.
Highlights
Cervical cancer continues to be the third most common malignancy in women worldwide [1], with an estimated global incidence of over 500000 new cases every year and approximately 265700 women deaths from this disease per year [2]. vaccination and screening for cervical cancer are helpful for prevention, early detection and standard treatments, such as radiotherapy, chemotherapy, and surgery, can lead to remission; clinical prognosis still varies significantly and is not easy to predict [3,4,5,6,7]
The results of the present study suggest that Tripartite motif containing 44 (TRIM44) expression was significantly up-regulated in cervical cancer specimens compared with adjacent normal tissues and was significantly associated with poor prognosis
Our study demonstrated that TRIM44 expression contributes to the progression of cervical cancer, and could be used as a marker of clinical diagnosis and prognosis of patients with cervical cancer
Summary
Cervical cancer continues to be the third most common malignancy in women worldwide [1], with an estimated global incidence of over 500000 new cases every year and approximately 265700 women deaths from this disease per year [2]. vaccination and screening for cervical cancer are helpful for prevention, early detection and standard treatments, such as radiotherapy, chemotherapy, and surgery, can lead to remission; clinical prognosis still varies significantly and is not easy to predict [3,4,5,6,7]. Cervical cancer continues to be the third most common malignancy in women worldwide [1], with an estimated global incidence of over 500000 new cases every year and approximately 265700 women deaths from this disease per year [2]. It is significant to explore the molecular pathogenesis of cervical cancer and identify prognostic markers to improve therapeutic strategies, and tumor biological behavior would be prognosticated reliably, effective treatment would be prescribed, patient care would be improved considerably. It has been demonstrated that Trim is involved in the development and progression of several malignant tumors [8,9,10,11,12,13,14,15,16].
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