Abstract
Magnesium oxide (MgO) as a highly effective heterogeneous base catalyst effectively catalyzes the three component reaction of aryl aldehydes, malononitrile and α-hydroxy or α-amino activated C–H acids such as 1,3-cyclohexanedione, dimedone, 4-hydroxy-6-methylpyrone, 4-hydroxycoumarin, 1,3-dimethylbarbituric acid and 1,3-dimethyl-6-amino uracil to the formation of the corresponding pyran annulated heterocyclic systems. The catalyst is inexpensive and easily obtained, stable and storable, easily recycled and reused for several cycles with consistent activity.
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