High-sulforaphane broccoli sprout powder reduces serum nitric oxide metabolites in Helicobacter pylori infected patients

Abstract

Pathological over production of nitric oxide (NO), induced by Helicobacter pylori, has been known as a risk factor for development of gastritis and gastric cancer. The current study investigated the effect of high-sulforaphane (SFN) broccoli sprouts powder on serum NO metabolites in H. pylori infected patients. Eighty-six patients with positive H. pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: Standard triple therapy (STT) for 14days, 6g/d broccoli sprouts powder (BSP) for 28days, and combination of these as STT (for 14days)+BSP (for 28days). Fasting serum NO metabolites were assessed at baseline and again after treatment. There was a significant decrease in serum NOx levels in BSP (25.2 vs. 51.6μmol/L, P<0.001) and STT+BSP (31.9vs. 44.3, μmol/L, P<0.05) groups after intervention. High-SFN present in broccoli sprouts, may attenuate undesirable overproduction of NO in H. pylori infected patients.